Protecting the Uterine Lining and Restoring Cycles: Prometrium (progesterone) is a prescription medication indicated to prevent endometrial hyperplasia in postmenopausal women with a uterus who are taking conjugated estrogens, and to treat secondary amenorrhea. It's often paired with estrogen therapy to help keep the uterine lining healthy.

Balancing Estrogen's Effect on the Uterus: Progesterone plays a key role in regulating the uterine lining, ensuring it grows and sheds appropriately rather than becoming abnormally thickened — a risk that can arise when estrogen is used without a progestin. In secondary amenorrhea, progesterone helps trigger the hormonal shift needed to restart a menstrual cycle.

Dosing Timed to Your Treatment Goal: For preventing endometrial hyperplasia, Prometrium is typically taken as 200 mg once daily at bedtime for 12 days per 28-day cycle, alongside daily conjugated estrogens. For secondary amenorrhea, a common regimen is 400 mg once daily at bedtime for 10 days, with the majority of women experiencing withdrawal bleeding as intended.

Micronized Progesterone With Strong Clinical Support: Prometrium's micronized formulation is designed to improve how well the body absorbs oral progesterone, and clinical studies have shown high rates of the intended withdrawal bleeding response in women with secondary amenorrhea, supporting its established role in these specific hormonal indications.

Restoring Balance, One Cycle at a Time: Whether protecting the uterine lining during estrogen therapy or helping restart a delayed cycle, Prometrium's role is about restoring hormonal balance. Your doctor can help determine the right regimen and duration based on your specific situation.

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