Delayed-Release Mesalamine for Ulcerative Colitis: Asacol and Delzicol are both delayed-release mesalamine formulations indicated for the treatment of mildly to moderately active ulcerative colitis and for maintaining remission afterward. Asacol is supplied as a delayed-release tablet, while Delzicol delivers the same mesalamine as a delayed-release capsule — giving patients and physicians flexibility in choosing the formulation that works best for them.

Anti-Inflammatory Action Where It's Needed: Both formulations use a special coating designed to protect the medication as it passes through the stomach and small intestine, releasing mesalamine once it reaches the colon. There, mesalamine is believed to exert a topical anti-inflammatory effect on the cells lining the colon, helping calm the inflammation that drives ulcerative colitis symptoms.

Dosing Tailored to Your Treatment Phase: For active disease, Asacol is typically dosed at two 800 mg tablets three times daily, while Delzicol is typically dosed at 800 mg (two 400 mg capsules) three times daily, both usually for six weeks. Maintenance dosing for both is generally 1.6 grams daily in divided doses. Tablets and capsules should always be swallowed whole, never cut, crushed, or chewed, to preserve their delayed-release properties.

Two Established Options, One Proven Mechanism: Mesalamine therapies have long been a cornerstone of mild-to-moderate ulcerative colitis treatment, and having both a tablet and capsule option available allows your doctor to choose the formulation best suited to your preferences or swallowing ability.

Working Toward Longer Stretches of Remission: Ulcerative colitis management is about extending the time between flares as much as it is about treating active symptoms. With consistent use of Asacol or Delzicol and regular follow-up with your gastroenterologist, many patients find a more predictable rhythm to their digestive health.

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